AbstractNew, innovative business venturing hinges on the creation and mobilization of human capital and knowledge. The proposals in this chapter aim to strengthen and expand the European knowledge space in which Europe’s entrepreneurs build their ventures. Reforms to improve the production and flow of knowledge touch on educational systems, research institutes, and universities. Whereas educational systems remain the almost exclusive legal competency of national or even regional policymakers, reforms addressing intellectual property and the mobility of knowledge and people across the European Union touch on supranational policy domains that extend the scope of entrepreneurship policy beyond its traditional policy areas.