Classical swine fever (CSF) caused by classical swine fever virus (CSFV), Pestivirus genus of the Flavivirdae family, is a highly contagious, multisystemic, and hemorrhagic disease of pigs and one of the most important disease in pig industry, economically and clinically. Domestic and wild pigs are the only natural reservoirs of CSFV. Since the first report of the outbreak of CSF in the early 19th century, a lot of attempts have been made to prevent and/or eradicate the disease. Many countries have successfully eradicated CSF due to the attempts and trials. However, some countries are still sporadic outbreak and/or endemic. Therefore, World Organization for Animal Health is still designated as a notifiable disease. As a step to prevent and/or eradicate the disease, vaccines have been developed. After reviewing etiology, clinical symptoms and diagnosis of CSF, development of vaccines, especially recent vaccines were intensively reviewed. Researches on plant-made vaccine candidates against CSF were introduced in this chapter.