Quality Assurance (QA) is an essential aspect of medical imaging, ensuring that X-ray imaging modalities provide adequate diagnostic information at exposures that are as low as reasonably/diagnostically acceptable (ALARA/ALADA), minimizing the potential radiation risk to the patient. This chapter covers the different elements of a QA program involving CBCT equipment, comprising quality control, patient dose monitoring, and clinical image quality assessment. Current guidelines regarding QA in CBCT are briefly summarized.