• Clinical examination of the breast is the weakest test of the “triple diagnostic assessment”, but may be decisive to solve many common symptoms as breast pain, inflammatory changes, acute enlargement of cysts, and many more. • The basic goal of clinical breast examination is to identify a palpable dominant mass, which by definition is a three-dimensional distinct mass that is different from the remainder of the breast tissue and from the tissue of the other breast (not symmetrical). • A dominant breast mass should be definitively diagnosed in a timely manner (old or already recorded, newly or firstly discovered, changing over time, etc.). • Even though a dominant mass in a woman under the age of 40 is most likely benign, a new dominant mass in a postmenopausal woman is most likely malignant.