This chapter contains a rich set of classroom-tested student-centered activities that can be easily integrated into existing science curricula to teach required science content as well as NOS concepts. Here we offer several engaging experiences for science students as well as preservice and inservice teachers. We have provided detailed instructional scenarios and diagrams so that the activities can be used easily and effectively. All major science disciplines are represented along with NOS ideas such as the notion that science knowledge may change through time (tentativeness), creativity, subjectivity, observation and inference, and the role of evidence.