This text is based on an invited address presented at IFIP 8.2 ‘Living with Monsters’ in San Francisco, CA, 11 December 2018. Taking the 200th anniversary of Mary Wollstonecraft Shelley’s Frankenstein as a starting place, I explore questions of autonomy and control with respect to human/technology relations. I consider the ambivalence of these agencies, and recent initiatives in science and technology studies and related fields to reconceptualize the problem as matters of relation and care. While embracing this turn, I reflect as well upon the ambivalences of relation and care, and the need to address the resilient politics of alterity in our figurations (and celebrations) of the monstrous.