Inhibition of Lipid Peroxidation by Purines and Analogues of Purine
Inhibition of Lipid Peroxidation by Purines and Analogues of Purine
The importance of oxygen radicals in tissue injury is widely recognized(1). Mutation, cancer, inflammation, and ageing are thought to be caused by oxygen radicals. It has also been confirmed that lipids are peroxidized by oxygen radicals leading to the damaging effects on cellular constituents. Mickel & Horbar(2) reported that peroxidized lipids affect platelet aggregation. The concentration of lipid peroxide in the arterial wall and the severity of atherosclerosis are positively correlated(3). These findings suggest a possible role of peroxidized lipids in the pathogenesis of atherosclerosis.
Erythrocyte Membrane, Hydrogen Peroxide, Ribonucleotides, Aminoimidazole Carboxamide, Thiobarbituric Acid Reactive Substances, Uric Acid, Structure-Activity Relationship, Ozone, Purines, Humans, Lipid Peroxidation
Erythrocyte Membrane, Hydrogen Peroxide, Ribonucleotides, Aminoimidazole Carboxamide, Thiobarbituric Acid Reactive Substances, Uric Acid, Structure-Activity Relationship, Ozone, Purines, Humans, Lipid Peroxidation
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