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Hormone, lectin and toxin-toxin conjugates

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Jan 1988Publisher:Springer US

Authors: Ronald G. Wiley; Thomas N. Oeltmann;

doi: 10.1007/978-1-4613-1083-9_16

pmid: 2908630

Hormone, lectin and toxin-toxin conjugates

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Abstract

In order to better understand the relative importance of the A and B chains of diphtheria toxin and ricin, chimeras or hybrid toxins have been constructed with diphtheria toxin subunits and ricin subunits coupled to a number of different binding moieties. These experiments have demonstrated wide variations in cytotoxicity depending on the specific combinations of A chain and binding moiety.

Keywords

Drug Carriers, Receptors, Cell Surface, Ligands, Placental Lactogen, Chorionic Gonadotropin, Hormones, Drug Design, Lectins, Receptors, Mitogen, Animals, Insulin, Thyrotropin-Releasing Hormone, Cells, Cultured, Toxins, Biological

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