Warehouse layouts, due to their influence on total warehousing costs, are of interest to the theory and practice of warehouse design. While the layout problem of unit-load storage area of conventional warehouses has quite a long history, the layout of conventional systems with manual order-picking from multiple aisles has been the topic of a number of research papers only in the previous decade. The research has resulted, among other things, in various models for optimal layout design. Moreover, some new innovative layouts for storage area have been proposed recently. These layouts result in a reduced travel distance needed to store or retrieve a single pallet, thus improving the efficiency in the storage area. However, the question of whether these layouts could perform better than traditional layouts in manual order-picking operations has remained unanswered. This chapter provides a short overview of optimal traditional layouts of the storage and orderpicking area as well as new innovative storage area layouts, followed by results of the analysis of orderpicking in these new innovative layouts and relevant conclusions.