Induction of PINK1/Parkin-Mediated Mitophagy
Induction of PINK1/Parkin-Mediated Mitophagy
PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are activated to promote the proteasomal degradation of mitochondrial outer membrane proteins and selective elimination of damaged mitochondria by autophagy. In this chapter, we describe the methods for induction of PINK1/Parkin-mediated mitophagy in tissue culture cell lines.
- Juntendo University Japan
Membrane Potential, Mitochondrial, PTEN-Induced Putative Kinase, Ubiquitin-Protein Ligases, Blotting, Western, Fluorescent Antibody Technique, Mitochondria, Mice, Gene Expression Regulation, Microscopy, Fluorescence, Autophagy, Animals, Humans, Protein Kinases, Protein Binding
Membrane Potential, Mitochondrial, PTEN-Induced Putative Kinase, Ubiquitin-Protein Ligases, Blotting, Western, Fluorescent Antibody Technique, Mitochondria, Mice, Gene Expression Regulation, Microscopy, Fluorescence, Autophagy, Animals, Humans, Protein Kinases, Protein Binding
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