Climate change in the Republic of Adygea was investigated on the base of monthly average data collected for the period 1900–2015 from the NOAA-CIRES-DOE Twentieth Century Reanalysis V3. The following basic meteo parameters have been selected for the analysis: air temperature at 2 m, max air temperature at 2 m, min air temperature at 2 m, sea level pressure, U wind component at 10 m, V wind component at 10 m, total cloud cover, total precipitation, snow depth. For every parameter we performed: (a) analysis of seasonal and interannual variability and its linear trend; (b) analysis of anomalies, including anomalies in warm and cold seasons; (c) spectral analysis; and (d) wavelet analysis. Extreme climate events in the Republic of Adygea were investigated for 1900–2015 on the base of analysis of seven basic meteo parameters (daily averaged): air temperature at 2 m, max air temperature at 2 m, min air temperature at 2 m, U (zonal) wind component at 10 m, V (meridional) wind component at 10 m, total precipitation, and snow depth. For every parameter we present six graphs: interannual variability of positive and negative amplitude of the climate extreme events over 1 and 2 standard deviations (SD); interannual variability of a number of these events over 1 and 2 SD; interannual variability of duration of these events over 1 and 2 SD. All the anomalies were calculated relative to the average annual cycle for the period 1900–2015. We considered the events “anomalous” when values of anomalies exceeded 1 SD and as “extreme” when anomalies exceeded 2 SD.