Ischemic heart disease (IHD) is the leading cause of morbidity and mortality in industrialized countries and poses an enormous financial burden on our society. As a consequence rational, evidence-based use of diagnostic and therapeutic means will be needed to prevent financial lapses and to guarantee an affordable medicine in the coming years. Magnetic resonance imaging is rapidly gaining widespread acceptance to investigate the full spectrum of patients presenting with symptoms of myocardial ischemia, ranging from stable coronary artery disease, over acute coronary syndrome, to the prediction of functional recovery post-revascularization in patients with chronic ischemic cardiomyopathy. In this chapter the MRI strategies to investigate IHD patients are discussed in detail, emphasizing the comprehensive approach converging information regarding myocardial perfusion, function and tissue characterization. Besides extensive illustration about the use of MRI, timelines for comprehensive MRI are provided for each IHD subgroup including standard and optional sequences.