Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts
Copyright policy )Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts
In this study the ability of soluble interleukin-6 receptor (sIL-6R) to stimulate interleukin-6 (IL-6) synthesis in human fibroblasts is described. It was found that sIL-6R, in combination with endogenous or exogenous IL-6, markedly upregulated IL-6 synthesis. These data suggest that increased IL-6 production after stimulation by either interleukin-1 or tumor necrosis factor-alpha would result in complex formation with sIL-6R, rapid uptake, and further synthesis of this cytokine. Furthermore, it would explain the decrease in sIL-6R plasma levels observed in patients suffering from sepsis.
- Johannes Gutenberg University of Mainz Germany
- University of Georgia Georgia
- Jagiellonian University Poland
- University of Georgia Press United States
Interleukin-6, Gene Expression, Receptors, Interleukin, Fibroblasts, Receptors, Interleukin-6, Recombinant Proteins, Kinetics, Antigens, CD, Humans, Cells, Cultured, Skin
Interleukin-6, Gene Expression, Receptors, Interleukin, Fibroblasts, Receptors, Interleukin-6, Recombinant Proteins, Kinetics, Antigens, CD, Humans, Cells, Cultured, Skin
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