Genomic Organization and Expression of Mouse Deoxyribonuclease I
Copyright policy )Genomic Organization and Expression of Mouse Deoxyribonuclease I
Deoxyribonuclease I (DNase I) has recently been implicated in cell death by apoptosis, a process which is frequently accompanied by chromatin DNA degradation. Despite extensive studies on DNase I, its genomic organisation remained unknown. Here we report for the first time on the intron-exon structure of the DNase I gene. The coding region of mouse DNase I is composed of eight introns and eight exons, spanning 2315 base pairs. The deduced protein sequence is 91.5% identical to its rat counterpart, but does not carry the two mutations (Glu13 to D and V67 to I) responsible for the decrease in actin-binding of rat DNase I. The enzymatic activity of mouse DNase I is found in striated muscle, kidney, intestine, liver, lymphnodes, but not in the heart, spleen or pancreas.
- University of Geneva Switzerland
- Institute of Biochemistry Switzerland
- University of Lausanne Switzerland
DNA, Complementary, Sheep, Base Sequence, Sequence Homology, Amino Acid, Swine, Myocardium, Molecular Sequence Data, Restriction Mapping, Gene Expression, Exons, Polymerase Chain Reaction, Protein Structure, Secondary, Rats, Mice, Animals, Deoxyribonuclease I, Humans, Cattle, Amino Acid Sequence, DNA Primers, Gene Library
DNA, Complementary, Sheep, Base Sequence, Sequence Homology, Amino Acid, Swine, Myocardium, Molecular Sequence Data, Restriction Mapping, Gene Expression, Exons, Polymerase Chain Reaction, Protein Structure, Secondary, Rats, Mice, Animals, Deoxyribonuclease I, Humans, Cattle, Amino Acid Sequence, DNA Primers, Gene Library
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