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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Statistics in Medici...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Statistics in Medicine
Article . 2020 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
zbMATH Open
Article . 2020
Data sources: zbMATH Open
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Copula modeling of receiver operating characteristic and predictiveness curves

Authors: Gabriel Escarela; Carlos Erwin Rodríguez; Gabriel Núñez‐Antonio;

Copula modeling of receiver operating characteristic and predictiveness curves

Abstract

Receiver operating characteristic (ROC) and predictiveness curves are graphical tools to study the discriminative and predictive power of a continuous‐valued marker in a binary outcome. In this paper, a copula‐based construction of the joint density of the marker and the outcome is developed for plotting and analyzing both curves. The methodology only requires a copula function, the marginal distribution of the marker, and the prevalence rate for the model to be characterized. The adoption of the Gaussian copula and the customization of the margin for the marker are proposed for such characterization. The computation of both curves is numerically more feasible than methods that attempt to obtain one curve in terms of the other. Estimation is carried out using maximum likelihood and resampling‐based methods. Randomized quantile residuals from each conditional distribution are employed for both assessing the adequacy of the model and identifying outliers. The performance of the estimators of both curves and their underlying quantities is evaluated in simulation studies that assume different dependence structures and sample sizes. The methods are illustrated with an analysis of the level of progesterone receptor gene expression for the diagnosis and prediction of estrogen receptor‐positive breast cancer.

Keywords

mixture model, AUC, Models, Statistical, convexity, Normal Distribution, bimodal distribution, Applications of statistics to biology and medical sciences; meta analysis, risk prediction, ROC Curve, Humans, Computer Simulation, non-Gaussian marker, skewed normal distribution, Biomarkers

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
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