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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Statistics in Medici...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Statistics in Medicine
Article . 2020 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
zbMATH Open
Article . 2020
Data sources: zbMATH Open
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Restricted mean survival time for interval‐censored data

Restricted mean survival time for interval-censored data
Authors: Chenyang Zhang; Yuanshan Wu; Guosheng Yin;

Restricted mean survival time for interval‐censored data

Abstract

Restricted mean survival time (RMST) evaluates the mean event‐free survival time up to a prespecified time point. It has been used as an alternative measure of treatment effect owing to its model‐free structure and clinically meaningful interpretation of treatment benefit for right‐censored data. In clinical trials, another type of censoring called interval censoring may occur if subjects are examined at several discrete time points and the survival time falls into an interval rather than being exactly observed. The missingness of exact observations under interval‐censored cases makes the nonparametric measure of treatment effect more challenging. Employing the linear smoothing technique to overcome the ambiguity, we propose a new model‐free measure for the interval‐censored RMST. As an alternative to the commonly used log‐rank test, we further construct a hypothesis testing procedure to assess the survival difference between two groups. Simulation studies show that the bias of our proposed interval‐censored RMST estimator is negligible and the testing procedure delivers promising performance in detecting between‐group difference with regard to size and power under various configurations of survival curves. The proposed method is illustrated by reanalyzing two real datasets containing interval‐censored observations.

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Keywords

Clinical Trials as Topic, nonparametric estimator, interval censoring, perturbation resampling, Survival Analysis, Applications of statistics to biology and medical sciences; meta analysis, restricted mean survival time, Survival Rate, Bias, two-sample test, Humans, Computer Simulation, Proportional Hazards Models

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Top 10%
Average
Top 10%
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