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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Statistics in Medici...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Statistics in Medicine
Article . 2019 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
zbMATH Open
Article . 2020
Data sources: zbMATH Open
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Randomization tests for multiarmed randomized clinical trials

Authors: Yanying Wang; William F. Rosenberger; Diane Uschner;

Randomization tests for multiarmed randomized clinical trials

Abstract

We examine the use of randomization‐based inference for analyzing multiarmed randomized clinical trials, including the application of conditional randomization tests to multiple comparisons. The view is taken that the linkage of the statistical test to the experimental design (randomization procedure) should be recognized. A selected collection of randomization procedures generalized to multiarmed treatment allocation is summarized, and generalizations for two randomization procedures that heretofore were designed for only two treatments are developed. We explain the process of computing the randomization test and conditional randomization test via Monte Carlo simulation, developing an efficient algorithm that makes multiple comparisons possible that would not be possible using a standard algorithm, demonstrate the preservation of type I error rate, and explore the relationship of statistical power to the randomization procedure in the presence of a time trend and outliers. We distinguish between the interpretation of thep‐value in the randomization test and in the population test and verify that the randomization test can be approximated by the population test on some occasions. Data from two multiarmed clinical trials from the literature are reanalyzed to illustrate the methodology.

Related Organizations
Keywords

Random Allocation, multiple treatment comparison, Research Design, generalized randomization procedures, Humans, randomization-based inference, Computer Simulation, Monte Carlo rerandomization test, Monte Carlo Method, Applications of statistics to biology and medical sciences; meta analysis, Randomized Controlled Trials as Topic

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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Top 10%
Top 10%
Top 10%
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