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Statistics in Medicine
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Statistics in Medicine
Article
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Article . 2017
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Smooth semi‐nonparametric (SNP) estimation of the cumulative incidence function

تقدير سلس شبه غير بارامتري (SNP) لوظيفة الحدوث التراكمي
Authors: Anh Nguyen Duc; Marcel Wolbers;
APC: 2,332.51 EUR

Smooth semi‐nonparametric (SNP) estimation of the cumulative incidence function

Abstract

This paper presents a novel approach to estimation of the cumulative incidence function in the presence of competing risks. The underlying statistical model is specified via a mixture factorization of the joint distribution of the event type and the time to the event. The time to event distributions conditional on the event type are modeled using smooth semi‐nonparametric densities. One strength of this approach is that it can handle arbitrary censoring and truncation while relying on mild parametric assumptions. A stepwise forward algorithm for model estimation and adaptive selection of smooth semi‐nonparametric polynomial degrees is presented, implemented in the statistical software R, evaluated in a sequence of simulation studies, and applied to data from a clinical trial in cryptococcal meningitis. The simulations demonstrate that the proposed method frequently outperforms both parametric and nonparametric alternatives. They also support the use of ‘ad hoc’ asymptotic inference to derive confidence intervals. An extension to regression modeling is also presented, and its potential and challenges are discussed. © 2017 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

Keywords

Artificial intelligence, Antifungal Agents, smooth semi-nonparametric (SNP) estimation, Genomic and Epidemiological Studies of Phytophthora Pathogens, Plant Science, Biostatistics, Meningitis, Cryptococcal, Statistics, Nonparametric, Applications of statistics to biology and medical sciences; meta analysis, Agricultural and Biological Sciences, Inference, Risk Factors, Genetic Diversity and Breeding of Wheat, FOS: Mathematics, Humans, Computer Simulation, Genome Sequencing, cumulative incidence function, Research Articles, Censoring (clinical trials), competing risks, Randomized Controlled Trials as Topic, Likelihood Functions, Models, Statistical, AIDS-Related Opportunistic Infections, Nonparametric statistics, interval censoring, Incidence, mixture factorization, Statistics, Life Sciences, Computer science, Parametric statistics, Genetics and Epidemiology of Plant Pathogens, Algorithms, Mathematics

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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