
This paper presents a novel approach to estimation of the cumulative incidence function in the presence of competing risks. The underlying statistical model is specified via a mixture factorization of the joint distribution of the event type and the time to the event. The time to event distributions conditional on the event type are modeled using smooth semi‐nonparametric densities. One strength of this approach is that it can handle arbitrary censoring and truncation while relying on mild parametric assumptions. A stepwise forward algorithm for model estimation and adaptive selection of smooth semi‐nonparametric polynomial degrees is presented, implemented in the statistical software R, evaluated in a sequence of simulation studies, and applied to data from a clinical trial in cryptococcal meningitis. The simulations demonstrate that the proposed method frequently outperforms both parametric and nonparametric alternatives. They also support the use of ‘ad hoc’ asymptotic inference to derive confidence intervals. An extension to regression modeling is also presented, and its potential and challenges are discussed. © 2017 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.
Artificial intelligence, Antifungal Agents, smooth semi-nonparametric (SNP) estimation, Genomic and Epidemiological Studies of Phytophthora Pathogens, Plant Science, Biostatistics, Meningitis, Cryptococcal, Statistics, Nonparametric, Applications of statistics to biology and medical sciences; meta analysis, Agricultural and Biological Sciences, Inference, Risk Factors, Genetic Diversity and Breeding of Wheat, FOS: Mathematics, Humans, Computer Simulation, Genome Sequencing, cumulative incidence function, Research Articles, Censoring (clinical trials), competing risks, Randomized Controlled Trials as Topic, Likelihood Functions, Models, Statistical, AIDS-Related Opportunistic Infections, Nonparametric statistics, interval censoring, Incidence, mixture factorization, Statistics, Life Sciences, Computer science, Parametric statistics, Genetics and Epidemiology of Plant Pathogens, Algorithms, Mathematics
Artificial intelligence, Antifungal Agents, smooth semi-nonparametric (SNP) estimation, Genomic and Epidemiological Studies of Phytophthora Pathogens, Plant Science, Biostatistics, Meningitis, Cryptococcal, Statistics, Nonparametric, Applications of statistics to biology and medical sciences; meta analysis, Agricultural and Biological Sciences, Inference, Risk Factors, Genetic Diversity and Breeding of Wheat, FOS: Mathematics, Humans, Computer Simulation, Genome Sequencing, cumulative incidence function, Research Articles, Censoring (clinical trials), competing risks, Randomized Controlled Trials as Topic, Likelihood Functions, Models, Statistical, AIDS-Related Opportunistic Infections, Nonparametric statistics, interval censoring, Incidence, mixture factorization, Statistics, Life Sciences, Computer science, Parametric statistics, Genetics and Epidemiology of Plant Pathogens, Algorithms, Mathematics
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