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PubMed Central
Article . 2025
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Statistics in Medicine
Article . 2025 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
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Accounting for Misclassification of Cause of Death in Weighted Cumulative Incidence Functions for Causal Analyses

Authors: Jessie K. Edwards; Bonnie E. Shook‐Sa; Giorgos Bakoyannis; Paul N. Zivich; Michael E. Herce; Stephen R. Cole;

Accounting for Misclassification of Cause of Death in Weighted Cumulative Incidence Functions for Causal Analyses

Abstract

ABSTRACT Misclassification between causes of death can produce bias in estimated cumulative incidence functions. When estimating causal quantities, such as comparing the cumulative incidence of death due to specific causes under interventions, such bias can lead to suboptimal decision making. Here, a consistent semiparametric estimator of the cumulative incidence function under interventions in settings with misclassification between two event types is presented. The measurement parameters for this estimator can be informed by validation data or expert knowledge. Moreover, a modified bootstrap approach to variance estimation is proposed for confidence interval construction. The proposed estimator was applied to estimate the cumulative incidence of AIDS‐related mortality in the Multicenter AIDS Cohort Study under single‐ versus combination‐drug antiretroviral therapy regimens that may be subject to confounding. The proposed estimator is shown to be consistent and performed well in finite samples via a series of simulation experiments.

Keywords

Acquired Immunodeficiency Syndrome, Models, Statistical, Anti-HIV Agents, Incidence, Article, Causality, Cohort Studies, Bias, Cause of Death, Confidence Intervals, Humans, Computer Simulation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green