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Statistics in Medicine
Article . 2025 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
https://dx.doi.org/10.48550/ar...
Article . 2024
License: arXiv Non-Exclusive Distribution
Data sources: Datacite
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Causal Inference With Outcomes Truncated by Death and Missing Not at Random

Authors: Wei Li; Yuan Liu; Shanshan Luo; Zhi Geng;

Causal Inference With Outcomes Truncated by Death and Missing Not at Random

Abstract

ABSTRACTIn clinical trials, principal stratification analysis is commonly employed to address the issue of truncation by death, where a subject dies before the outcome can be measured. However, in practice, many survivor outcomes may remain uncollected or be missing not at random, posing a challenge to standard principal stratification analysis. In this article, we explore the identification, estimation, and bounds of the average treatment effect within a subpopulation of individuals who would potentially survive under both treatment and control conditions. We show that the causal parameter of interest can be identified by introducing a proxy variable that affects the outcome only through the principal strata, while requiring that the treatment variable does not directly affect the missingness mechanism. Subsequently, we propose an approach for estimating causal parameters and derive nonparametric bounds in cases where identification assumptions are violated. We illustrate the performance of the proposed method through simulation studies and a real dataset obtained from a human immunodeficiency virus study.

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Keywords

FOS: Computer and information sciences, Clinical Trials as Topic, Models, Statistical, Methodology, HIV Infections, Causality, Methodology (stat.ME), Treatment Outcome, Data Interpretation, Statistical, Applications, Humans, Computer Simulation, Applications (stat.AP), Randomized Controlled Trials as Topic

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green