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Statistics in Medicine
Article . 2012 . Peer-reviewed
License: Wiley Online Library User Agreement
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Sensitivity of the discrete‐time Kaplan–Meier estimate to nonignorable censoring: Application in a clinical trial

Authors: Tao, Liu; Daniel F, Heitjan;

Sensitivity of the discrete‐time Kaplan–Meier estimate to nonignorable censoring: Application in a clinical trial

Abstract

Untestable assumptions about the association between survival and censoring times can affect the validity of estimates of the survival distribution including the Kaplan–Meier (KM) nonparametric maximum likelihood estimate (MLE). This paper explores the sensitivity of the KM curve to nonignorable censoring by extending the index of local sensitivity to nonignorability (ISNI; Troxelet al.,Statistica Sinica,14, 1221–1237, 2004; Zhang and Heitjan,Biometrics,62, 1260–1268, 2006) to the case of a nonparametric survival model. The method involves, first, specifying a coarse‐data selection model to describe the association between the failure and censoring processes and then evaluating the slope of the nonparametric survival MLE ordinate with respect to a nonignorability parameter in the neighborhood of the ignorable model. We define the nonparametric MLE of the survival curve for a fixed value of the nonignorability parameter and show in a simulation that ISNI analysis effectively captures local sensitivity to nonignorability. The method measures sensitivity in the sense of identifying functionals of the nonparametric MLE that nonignorability, if present, can affect substantially. We demonstrate the method with an application to a trial comparing mechanical assistance to optimal medical management in the treatment of end‐stage heart failure. Copyright © 2012 John Wiley & Sons, Ltd.

Related Organizations
Keywords

Clinical Trials as Topic, Data Interpretation, Statistical, Kaplan-Meier Estimate, Sensitivity and Specificity

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
bronze