Exact power computation for dose—response studies
Copyright policy )Exact power computation for dose—response studies
AbstractThe toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose‐response study. We present a method for computing the exact power of exact and large sample statistical tests employed for binary response data from such a study. This method, based on recursive polynomial multiplications, enables fast computation of exact power for studies with up to a moderately large sample size. We demonstrate the efficiency of our method using three examples. The method is suitable for the design and power analysis of dose—response studies in which the usual asymptotic approximations are suspect.
- University of California, Los Angeles United States
- University of Bergen Norway
Adenoma, Male, Dose-Response Relationship, Drug, GABA Agents, Methanol, Reproducibility of Results, Rats, Embryonic and Fetal Development, Mice, Logistic Models, Pregnancy, Sample Size, Linear Models, Animals, Humans, Female, Pituitary Neoplasms, Rats, Wistar, Algorithms, Software
Adenoma, Male, Dose-Response Relationship, Drug, GABA Agents, Methanol, Reproducibility of Results, Rats, Embryonic and Fetal Development, Mice, Logistic Models, Pregnancy, Sample Size, Linear Models, Animals, Humans, Female, Pituitary Neoplasms, Rats, Wistar, Algorithms, Software
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