
doi: 10.1002/sim.4127
pmid: 21337356
AbstractChange point models are used to describe processes over time that show a change in direction. An example of such a process is cognitive ability, where a decline a few years before death is sometimes observed. A broken‐stick model consists of two linear parts and a breakpoint where the two lines intersect. Alternatively, models can be formulated that imply a smooth change between the two linear parts. Change point models can be extended by adding random effects to account for variability between subjects. A new smooth change point model is introduced and examples are presented that show how change point models can be estimated using functions in R for mixed‐effects models. The Bayesian inference using WinBUGS is also discussed. The methods are illustrated using data from a population‐based longitudinal study of ageing, the Cambridge City over 75 Cohort Study. The aim is to identify how many years before death individuals experience a change in the rate of decline of their cognitive ability. Copyright © 2010 John Wiley & Sons, Ltd.
Aging, Likelihood Functions, Stochastic Processes, Models, Statistical, 330, Bayes Theorem, 510, Cohort Studies, Cognition, Data Interpretation, Statistical, Humans, Longitudinal Studies, Aged
Aging, Likelihood Functions, Stochastic Processes, Models, Statistical, 330, Bayes Theorem, 510, Cohort Studies, Cognition, Data Interpretation, Statistical, Humans, Longitudinal Studies, Aged
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