An analysis for a cross‐over cohort study with an application to the study of triggers of Menière's disease
Copyright policy )An analysis for a cross‐over cohort study with an application to the study of triggers of Menière's disease
AbstractWhen studying the effect of a transient exposure on the risk of a rare illness, for time and cost effectiveness it is desirable to follow a cohort of individuals who are ‘prone’ to the illness over an observation period. In this paper, we present a method of analysis for data arising from such a study. The proposed method can be used to estimate the relative risk of an exposure triggering the illness and the distribution of the time delay from exposure to the onset of illness. The model is extended to include covariate effects and to the situation where there are two types of exposure. For the two types of exposures situation, a model to handle a possible synergism of the exposures is proposed. Finally, the method is applied to study the potential triggers of attacks of Menière's disease. Copyright © 2006 John Wiley & Sons, Ltd.
- Karolinska Institute Sweden
- Centre for Mental Health United Kingdom
- Australian National University Australia
Log-linear model, head movement, data analysis, environmental exposure, Risk Assessment, Cohort Studies, health statistics, Case-cross-over, Hazard period, Humans, Keywords: acoustic stress, human, acute disease, loglinear model, Meniere Disease, clinical article, emotional stress, Cross-Over Studies, disease predisposition, article, Synergism, probability Acute illness, cohort analysis, covariance, Meniere disease, Acute Disease, Linear Models
Log-linear model, head movement, data analysis, environmental exposure, Risk Assessment, Cohort Studies, health statistics, Case-cross-over, Hazard period, Humans, Keywords: acoustic stress, human, acute disease, loglinear model, Meniere Disease, clinical article, emotional stress, Cross-Over Studies, disease predisposition, article, Synergism, probability Acute illness, cohort analysis, covariance, Meniere disease, Acute Disease, Linear Models
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