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Multiple Imputation for Longitudinal Data: A Tutorial

Multiple imputation for longitudinal data: a tutorial
Authors: Rushani Wijesuriya; Margarita Moreno‐Betancur; John B. Carlin; Ian R. White; Matteo Quartagno; Katherine J. Lee;

Multiple Imputation for Longitudinal Data: A Tutorial

Abstract

ABSTRACTLongitudinal studies are frequently used in medical research and involve collecting repeated measures on individuals over time. Observations from the same individual are invariably correlated and thus an analytic approach that accounts for this clustering by individual is required. While almost all research suffers from missing data, this can be particularly problematic in longitudinal studies as participation often becomes harder to maintain over time. Multiple imputation (MI) is widely used to handle missing data in such studies. When using MI, it is important that the imputation model is compatible with the proposed analysis model. In a longitudinal analysis, this implies that the clustering considered in the analysis model should be reflected in the imputation process. Several MI approaches have been proposed to impute incomplete longitudinal data, such as treating repeated measurements of the same variable as distinct variables or using generalized linear mixed imputation models. However, the uptake of these methods has been limited, as they require additional data manipulation and use of advanced imputation procedures. In this tutorial, we review the available MI approaches that can be used for handling incomplete longitudinal data, including where individuals are clustered within higher‐level clusters. We illustrate implementation with replicable R and Stata code using a case study from the Childhood to Adolescence Transition Study.

Keywords

FOS: Computer and information sciences, longitudinal data, Models, Statistical, multiple imputation, Adolescent, fully conditional specification, Statistics - Applications, Applications of statistics to biology and medical sciences; meta analysis, joint modeling, Methodology (stat.ME), missing data, Tutorial in Biostatistics, Data Interpretation, Statistical, Humans, Cluster Analysis, clustered data, Applications (stat.AP), Longitudinal Studies, Child, Statistics - Methodology

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    17
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
17
Top 10%
Average
Top 10%
Green
hybrid