Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1995 English Publisher:WileyJournal:Phytotherapy Research, volume 9, pages 600-602 (issn: 0951-418X, eissn: 1099-1573,

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Authors: Roseline Aliyu; Z. S. C. Okoye; W. Thomas Shier;

doi: 10.1002/ptr.2650090815

Cochlospermum planchonii rhizome extract with hepatoprotective activity inhibits cytochrome P‐450 monooxygenases

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Abstract

AbstractAn aqueous extract of Cochlospermum planchonii rhizomes prepared in the manner used by native medical practitioners in northern Nigeria to treat jaundice protects CCI4‐treated rats from liver damage measured as elevated serum levels of diagnostic enzymes. The extract inhibits cytochrome P‐450 monoxygenases aminopyrine‐N‐demethylase and aniline hydroxylase, suggesting a plausible hepatoprotective mechanism.

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