Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba

descriptionPublicationkeyboard_double_arrow_right Article 17 Aug 2007 English Publisher:WileyJournal:Phytotherapy Research, volume 22, pages 256-258 (issn: 0951-418X, eissn: 1099-1573,

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Authors: Thierry, Hennebelle; Sevser, Sahpaz; Bernard, Gressier; Henry, Joseph; François, Bailleul;

doi: 10.1002/ptr.2266

pmid: 17705148

Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba

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Abstract

AbstractThe neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABAA receptors. The most active compound was luteolin‐7‐diglucuronide, with half maximal inhibitory concentrations (IC50) of 101 and 40 µm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin‐7‐diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical‐anion in cell‐free (hypoxanthine‐xanthine oxidase) and cellular (PMA‐stimulated neutrophil granulocytes) systems. Copyright © 2007 John Wiley & Sons, Ltd.

Related Organizations

University of Lille
France
UNIVERSITE LILLE 1
France

Keywords

Flavonoids, Male, Molecular Structure, Neutrophils, Plant Extracts, Biphenyl Compounds, Polyphenols, Free Radical Scavengers, Binding, Competitive, Antioxidants, Hydrazines, Phenols, Picrates, Humans, Hypnotics and Sedatives, Female, Iridoids, Reactive Oxygen Species, Lippia, Oxidation-Reduction

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