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Pharmaceutical Statistics
Article . 2014 . Peer-reviewed
License: Wiley Online Library User Agreement
Data sources: Crossref
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Balance and randomness in sequential clinical trials: the dominant biased coin design

Authors: BALDI ANTOGNINI, ALESSANDRO; ZAGORAIOU, MAROUSSA;

Balance and randomness in sequential clinical trials: the dominant biased coin design

Abstract

AbstractEfron's biased coin design (BCD) is a well‐known randomization technique that helps neutralize selection bias, while keeping the experiment fairly balanced for every sample size. Several extensions of this rule have been proposed, and their properties were analyzed from an asymptotic viewpoint and compared via simulations in a finite setup. The aim of this paper is to push forward these comparisons by taking also into account the adjustable BCD, which is never considered up to now. Firstly, we show that the adjustable BCD performs better than Efron's coin with respect to both loss of precision and randomness. Moreover, the adjustable BCD is always more balanced than the other coins and, only for some sample sizes, slightly more predictable. Therefore, we suggest the dominant BCD, namely a new and flexible class of procedures that can change the allocation rule step by step in order to ensure very good performance in terms of both balance and selection bias for any sample size. Our simulations demonstrate that the dominant BCD is more balanced and, at the same time, less or equally predictable than Atkinson's optimum BCD. Copyright © 2014 John Wiley & Sons, Ltd.

Country
Italy
Keywords

Clinical Trials as Topic, Random Allocation, Bias, Research Design, Humans, admissibility; balance; loss of information; predictability; selection bias

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Average
Average
Top 10%
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