Effects of ligands or substrate of insulin‐regulated aminopeptidase (IRAP) on trophoblast invasion
Copyright policy )Effects of ligands or substrate of insulin‐regulated aminopeptidase (IRAP) on trophoblast invasion
AbstractInsulin‐regulated aminopeptidase (IRAP) activity increases during placentation and in the invasive tumor cell of trophoblast suggesting a role for this peptidase in the invasiveness of normal and malignant trophoblast. To investigate this hypothesis, we studied the effects of substrate (OT) and inhibitors (angiotensin peptides and LVV‐H7) of IRAP on the first trimester trophoblast proliferation and invasion. Addition of these peptides in the culture medium of trophoblastic cells significantly decreased metalloproteinase‐9 activity and cellular invasiveness while no effect was observed on cell proliferation. The peptide IRAP inhibitors could exert their effect on cytotrophoblastic cell invasiveness by inhibition of its enzymatic activity, and thus increasing half life of the known placental peptide substrate of IRAP, OT. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.
- University of Geneva Switzerland
- University of Melbourne Australia
Enzyme Inhibitors/pharmacology, Ligands, Cell Line, Substrate Specificity, Trophoblasts, 618, Cell Proliferation/drug effects, Cystinyl Aminopeptidase/antagonists & inhibitors/metabolism, Matrix Metalloproteinase 9, Cystinyl Aminopeptidase, Matrix Metalloproteinase 9/metabolism, Enzyme Inhibitors, Trophoblasts/drug effects/metabolism, Cell Proliferation
Enzyme Inhibitors/pharmacology, Ligands, Cell Line, Substrate Specificity, Trophoblasts, 618, Cell Proliferation/drug effects, Cystinyl Aminopeptidase/antagonists & inhibitors/metabolism, Matrix Metalloproteinase 9, Cystinyl Aminopeptidase, Matrix Metalloproteinase 9/metabolism, Enzyme Inhibitors, Trophoblasts/drug effects/metabolism, Cell Proliferation
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