AbstractHerbicide‐tolerant (HT) varieties of corn, soybean, canola (oilseed rape) and cotton have been grown since the mid‐1990s, and have been widely adopted by farmers in several countries. HT genes have been inserted into or selected for in many other species, including almost all major crop species in the world and many minor crops and ornamental species. In some cases this has been done specifically to introduce the HT trait, whereas in others the HT gene has been used as a selectable marker (eg the bar gene, conferring glufosinate‐ammonium tolerance). However, in very few cases have the HT crops generated been commercialized, despite the weed‐control advantages that many such crops would offer. There are several reasons for this, including the high research and development costs associated with developing the new HT crop cultivars, the high cost of obtaining regulatory clearance for the HT crops or products derived from them, international trade issues relating to genetically modified crops, and issues surrounding the expanded herbicide registration for the new use and the potential impact of this on the existing registration status of the herbicide. New HT crops are unlikely to be developed unless they offer a sufficiently large advantage to farmers and a substantial assured market to justify the associated development and regulatory costs. Copyright © 2005 Society of Chemical Industry