Integrative structure modeling with the Integrative Modeling Platform
Copyright policy )Integrative structure modeling with the Integrative Modeling Platform
AbstractBuilding models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrative structure modeling casts the building of structural models as a computational optimization problem, for which information about the assembly is encoded into a scoring function that evaluates candidate models. Here, we describe our open source software suite for integrative structure modeling, Integrative Modeling Platform (https://integrativemodeling.org), and demonstrate its use.
- French National Centre for Scientific Research France
- CNRS (LCP) France
- CNRS France
- University of California, San Francisco United States
- University of California, Davis United States
Models, Molecular, 570, 1.1 Normal biological development and functioning, hybrid modeling, Bioinformatics and Computational Biology, Biophysics, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Bioengineering, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Underpinning research, Models, Medicinal and biomolecular chemistry, integrative modeling, structural biology, Computer Simulation, Other Information and Computing Sciences, Molecular, Computational Biology, Computation Theory and Mathematics, Biological Sciences, computational optimization, Networking and Information Technology R&D (NITRD), Biochemistry and cell biology, Chemical Sciences, Biochemistry and Cell Biology, Software
Models, Molecular, 570, 1.1 Normal biological development and functioning, hybrid modeling, Bioinformatics and Computational Biology, Biophysics, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Bioengineering, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Underpinning research, Models, Medicinal and biomolecular chemistry, integrative modeling, structural biology, Computer Simulation, Other Information and Computing Sciences, Molecular, Computational Biology, Computation Theory and Mathematics, Biological Sciences, computational optimization, Networking and Information Technology R&D (NITRD), Biochemistry and cell biology, Chemical Sciences, Biochemistry and Cell Biology, Software
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