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Liver Transplantation
Article . 2011 . Peer-reviewed
License: Wiley Online Library User Agreement
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Model for end-stage liver disease exceptions in the context of the french model for end-stage liver disease score–based liver allocation system

Authors: Claire, Francoz; Jacques, Belghiti; Denis, Castaing; Olivier, Chazouillères; Jean-Charles, Duclos-Vallée; Christophe, Duvoux; Jan, Lerut; +8 Authors

Model for end-stage liver disease exceptions in the context of the french model for end-stage liver disease score–based liver allocation system

Abstract

Model for End-Stage Liver Disease (MELD) score–based allocation systems have been adopted by most countries in Europe and North America. Indeed, the MELD score is a robust marker of early mortality for patients with cirrhosis. Except for extreme values, high pretransplant MELD scores do not significantly affect posttransplant survival. The MELD score can be used to optimize the allocation of allografts according to a sickest first policy. Most often, patients with small hepatocellular carcinomas (HCCs) and low MELD scores receive extra points, which allow them appropriate access to transplantation comparable to the access of patients with advanced cirrhosis and high MELD scores. In addition to patients with advanced cirrhosis and HCC, patients with a number of relatively uncommon conditions have low MELD scores and a poor prognosis in the short term without transplantation but derive excellent benefits from transplantation. These conditions, which correspond to the so-called MELD score exceptions, justify the allocation of a specific score for appropriate access to transplantation. Here we report the conclusions of the French consensus meeting. The goals of this meeting were (1) to identify which conditions merit MELD score exceptions, (2) to list the criteria needed for defining each of these conditions, and (3) to define a reasonable time interval for organ allocation for each MELD exception in the general context of organ shortages. MELD exceptions were discussed in an attempt to reconcile the concepts of transparency, equity, justice, and utility. Liver Transpl 17:1137–1151, 2011. © 2011 AASLD.

Keywords

Time Factors, Tissue and Organ Procurement, Waiting Lists, Patient Selection, Risk Assessment, Tissue Donors, Consensus Statements as Topic, Decision Support Techniques, Liver Transplantation, End Stage Liver Disease, Treatment Outcome, Risk Factors, Health Status Indicators, Humans, France

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
79
Top 10%
Top 10%
Top 10%
bronze