Intragranular starch: Comparison of starch USP and modified cornstarch
Copyright policy )Intragranular starch: Comparison of starch USP and modified cornstarch
Incorporation of starch USP or a modified cornstarch within the granules of several drug formulations was investigated. In general, the formulation containing the modified starch exhibited improved processing characteristics as well as improved tablet properties. A comparison of a granulated and a direct compression formulation of the same ingradients indicated that granulation of an active ingredient is not necessarily detrimental to its (pharmaceutical) availability.
- Merck & Co. United States
Probenecid, Starch, Ascorbic Acid, Chlorothiazide, Biopharmaceutics, Dihydroxyphenylalanine, Excipients, Kinetics, Solubility, Pressure, Hardness Tests, Methyldopa, Cellulose, Acetaminophen, Tablets
Probenecid, Starch, Ascorbic Acid, Chlorothiazide, Biopharmaceutics, Dihydroxyphenylalanine, Excipients, Kinetics, Solubility, Pressure, Hardness Tests, Methyldopa, Cellulose, Acetaminophen, Tablets
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