AbstractVirtual reality exposure (VRE) therapy is a promising treatment for a variety of anxiety disorders and has recently been extended to the treatment of posttraumatic stress disorder (PTSD). In this article, the authors briefly review the rationale for VRE and its key processes. They illustrate the treatment with an active‐duty Army soldier diagnosed with combat‐related PTSD. Six sessions of VRE were provided using an immersive simulation of a military convoy in Iraq. Self‐reported PTSD symptoms and psychological distress were reduced at posttreatment relative to pretreatment reports, as assessed by the PTSD Checklist–Military Version and the Behavior and Symptom Identification Scale–24. The case outcomes parallel those reported in the research with other disorders and suggest the applicability of VRE in treating active duty soldiers with combat‐related PTSD. © 2008 Wiley Periodicals, Inc. J Clin Psychol: In Session 64:1–7, 2008.