AbstractTo study the influence of the blade curvature radius on the flow‐induced vibration and noise of the centrifugal pump, the internal sound field of the IS 80‐65‐160 centrifugal pump was numerically calculated by adjusting the blade wrap angles to change the blade curvature radius. The RNG (Reynolds Time Average Simulation) turbulence model was selected for the numerical calculation of the centrifugal pump. The numerical simulation of the whole flow channel of the centrifugal pump was carried out using Ansys Fluent software, and the external characteristic curve of the centrifugal pump was obtained. The influence of different blade wrap angles on the internal pressure, velocity and Turbulent Kinetic Energy of the centrifugal pump was obtained. On the basis of the sound–structure coupling equation, the unsteady sound field of the centrifugal pump was calculated, and the time domain and frequency domain characteristics of the pressure pulsation at each monitoring point were obtained. The calculation results showed that the dynamic and static interference between the impeller and the volute tongue mainly caused the vibration of the centrifugal pump. By appropriately increasing the blade wrap angles, the pressure pulsation in the volute fluid domain could be effectively reduced. The vibration and noise test bench of the centrifugal pump was set up to verify the test. The experimental results showed that at the double‐blade frequency, the variation trend of the experimental value and the simulated value of the outflow flow‐induced noise of the centrifugal pump were consistent, which verified the accuracy of the sound field simulation calculation. When the blade wrap angle , it could effectively reduce the internal sound pressure level and the flow‐induced vibration and noise of the centrifugal pump. By adopting measures such as grid encryption at the position of the tongue, nonstationary calculation and comparison of different turbulence models, the accuracy of the calculation results of the internal flow field and sound field of the centrifugal pump is effectively improved, and the accuracy and reliability of the experimental results are ensured. The above research results had certain reference significance and application value for improving the working efficiency of centrifugal pumps and reducing flow‐induced vibration and noise.