Statistical issues on the determination of the no‐observed‐adverse‐effect levels in toxicology

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2001 English Publisher:WileyJournal:Environmetrics, volume 12, pages 319-325 (issn: 1180-4009, eissn: 1099-095X,

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Authors: Takashi Yanagawa; Yasuki Kikuchi;

doi: 10.1002/env.467

Statistical issues on the determination of the no‐observed‐adverse‐effect levels in toxicology

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Abstract

AbstractThe determination of a safe exposure level for toxic agents, often defined as the highest dose level with no toxic effect and termed the no‐observed‐adverse‐effect level (NOAEL) is reviewed. The conventional methods based on statistical tests are criticized, particularly when the sample size is small, and an alternative method, which is based on the Akaike information criterion (AIC), is discussed. The method is extended to the estimation of the NOAEL for continuous data. Computer programs for Windows 95/NT for determining the NOAEL by the AIC approach are developed and its application to practical data is illustrated with examples. Copyright © 2001 John Wiley & Sons, Ltd.

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