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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Clinical Pharmacolog...arrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Clinical Pharmacology & Therapeutics
Article . 1969 . Peer-reviewed
License: Wiley Online Library User Agreement
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Toxic and therapeutic effects of EMTP in obesity

Authors: D R, Hollingsworth; T T, Amatruda;

Toxic and therapeutic effects of EMTP in obesity

Abstract

EMTP (Fenfluramine), a new anorexigenic drug without properties that stimulate the central nervous system, was used as an ad;unct to an 800 calorie diet in a 120 day, double‐blind, randomized control study of 36 obese veterans. The greatest weight loss occurred in patients who were given the drug in Period 1 of the study and the least occurred in patients given placebo in Period 11. Although EMTP appeared more effective than the placebo, its results were not dramatic (nor statistically significant). The drug caused mild to moderately severe side effects in 25 of 36 patients whereas there were only mild complaints in 11 of 28 patients receiving the placebo. The large percentage of side effects may reflect the high dosage schedule in this drug trial. There was impotence in two men. Since most obesity drug evaluations are done in obese women, this effect might be missed.

Related Organizations
Keywords

Adult, Male, Clinical Trials as Topic, Diet, Reducing, Fluorine, Middle Aged, Placebos, Appetite Depressants, Fenfluramine, Phenethylamines, Humans, Female, Obesity, Aged

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Average
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