Metabolism of classical cannabinoids and the synthetic cannabinoid JWH‐018
Copyright policy )Metabolism of classical cannabinoids and the synthetic cannabinoid JWH‐018
Although the putative pharmacological targets of synthetic cannabinoids (SCBs) abused in “K2” and “Spice” are similar to Δ9‐tetrahydrocannabinol (Δ9‐THC), it remains unclear why SCB toxicity is similar yet different from marijuana. There are obvious potency and efficacy differences, but also important metabolic differences that help explain the unique adverse reactions associated with SCBs. This brief review discusses the limited research on the metabolism of the SCB JWH‐018 and contrasts that with the metabolism of Δ9‐THC.
- New York University United States
- University of Arkansas for Medical Sciences United States
- Arkansas Department of Health United States
Indoles, Cytochrome P-450 CYP2D6, Receptor, Cannabinoid, CB1, Cannabinoids, Humans, Dronabinol, Glucuronosyltransferase, Naphthalenes
Indoles, Cytochrome P-450 CYP2D6, Receptor, Cannabinoid, CB1, Cannabinoids, Humans, Dronabinol, Glucuronosyltransferase, Naphthalenes
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