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Cochrane Evidence Synthesis and Methods
Article . 2025 . Peer-reviewed
License: CC BY
Data sources: Crossref
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PubMed Central
Article . 2025
License: CC BY
Data sources: PubMed Central
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Count data, rates, rate differences, and rate ratios in meta‐analysis: A tutorial

Authors: Christopher James Rose; Milena Geist; Matteo Bruschettini;

Count data, rates, rate differences, and rate ratios in meta‐analysis: A tutorial

Abstract

Abstract This tutorial focuses on trials that assess outcomes by counting events that can occur zero, one, or more than one time in each participant. Trials and meta‐analyses can estimate treatment effects for count outcomes using rate differences or rate ratios. We explain why it may be appropriate to meta‐analyze count data to estimate rate ratios rather than odds ratios, risk ratios, or risk differences. We explain what count data are, how trials may estimate treatment effects, how to interpret such estimates, and how to extract data from trials that use count outcomes for meta‐analysis. Finally, we discuss some common misunderstandings and subtleties. Supplementary materials include an Excel file for performing calculations, mathematical background, and additional advice.

Keywords

Tutorial

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    5
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Top 10%
Average
Top 10%
Green
gold