AbstractBackgroundQuantitative flow ratio (QFR) is a novel, software‐based method to evaluate the physiology of coronary lesions. The aim of this study was to compare QFR with the established invasive measurements of coronary blood flow using instantaneous wave‐free ratio (iFR) or resting full‐cycle ratio (RFR) in daily cathlab routine.Methods102 patients with stable coronary artery disease and a coronary stenosis of 40%−90% were simultaneously assessed with QFR and iFR or RFR. QFR‐computation was performed by two certified experts using the appropriate software (QAngio XA 3D 3.2).ResultsQFR showed a significant correlation (r = 0.75, p < 0.001) to iFR and RFR. The area under the receiver curve for all measurements was 0.93 (95% confidence interval, 0.87–0.98) for QFR compared to iFR or RFR. QFR based assessment required less time with a median of 501 s (IQR 421–659 s) compared to iFR or RFR which required a median of 734 s to obtain the result (IQR 512–967 s; p < 0.001). The median use of contrast medium was similar with 21 mL (IQR 16–30 mL) for the QFR‐based and 22 mL (IQR 15–35 mL) for the iFR‐ or RFR‐based diagnostic. QFR diagnostic required less radiation. The median dose area product for QFR was 307cGycm2 (IQR 151–429 cGycm2) compared to 599 cGycm2 (IQR 345–1082 cGycm2) for iFR or RFR, p < 0.001.ConclusionQFR measurements of coronary artery blood flow correlate with iFR or RFR measurements and are associated with shorter procedure times and reduced radiation dose.