BackgroundHeart Team (HT) and the SYNTAX Score II (SSII) have been integrated to the contemporary guidelines with the aim to provide a multidisciplinary decision‐making process between coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI).AimsTo prospectively assess the agreement between the HT decision and the SSII recommendation regarding the revascularization strategy in patients with 3‐vessel coronary artery disease (CAD) of the SYNTAX II trial.MethodsThe SSII predicts the 4‐year mortality of an individual patient both after PCI and after CABG. Patients were treated by PCI when the SSII predicted a mortality risk favoring PCI or when risk predictions were equipoise between PCI and CABG. However, the HT could overrule the SSII and recommend either CABG or PCI.ResultsA total of 202 patients have been screened and 24 did not fulfill inclusion criteria. The median age was 67.0 (IQR 59.0–73.3), and 167 (82.7%) were male. The HT endorsed SSII treatment recommendation, for CABG or PCI, in 152 patients (85.4%). Three patients had preference for PCI, irrespective of the HT decision. The main reason for the HT to overrule the SSII and recommend CABG was the prospect of a more complete revascularization (21 of 25 patients). Patients recommended for CABG by the HT had significantly higher anatomical SYNTAX score (P = 0.03) and higher predicted mortality risk for PCI (P = 0.04) when compared with patients that were enrolled in the trial.ConclusionThe SYNTAX score II showed to be a suitable tool for guiding treatment decisions of patients with 3‐vessel coronary artery disease being endorsed by the HT in the vast majority of the patients that have been enrolled in the SYNTAX II trial. © 2015 Wiley Periodicals, Inc.