Next‐Generation Nucleic Acid Aptamers with Two‐Base‐Modified Nucleotides Have Improved Binding Affinity and Potency

descriptionPublicationkeyboard_double_arrow_right Article 26 Jun 2017 English Publisher:WileyJournal:ChemBioChem, volume 18, pages 1,565-1,567 (issn: 1439-4227, eissn: 1439-7633,

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Authors: Hadi, AlShamaileh; Rakesh N, Veedu;

doi: 10.1002/cbic.201700276

pmid: 28544018

Next‐Generation Nucleic Acid Aptamers with Two‐Base‐Modified Nucleotides Have Improved Binding Affinity and Potency

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Abstract

Twice as apt: Nucleic acid aptamers with high binding affinity, specificity, epitope coverage and nuclease resistance were developed by using libraries containing oligonucleotides in which two bases in the pyrimidine nucleotide had been modified.

Related Organizations

Perron Institute for Neurological and Translational Science
Australia
Murdoch University
Australia

Keywords

PCSK9 Inhibitors, Haplorhini, Aptamers, Nucleotide, Rats, Lipoproteins, LDL, Mice, Drug Design, Animals, Humans, Pyrimidine Nucleotides, Proprotein Convertase 9

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