Identification and Characterization of a Small‐Molecule Inhibitor of Death‐Associated Protein Kinase 1
Copyright policy )Identification and Characterization of a Small‐Molecule Inhibitor of Death‐Associated Protein Kinase 1
A novel imidazo-pyramidazine inhibitor of DAPK1 that undergoes class-specific interactions and extends into the substrate recognition site has been identified. This inhibitor is a good starting point for the development of selective and potent inhibitors of DAPK1, with potential use against stroke and ischemia.
- Structural Genomics Consortium Canada
- University of Oxford United Kingdom
- University of Copenhagen Denmark
- Novo Nordisk (Denmark) Denmark
- University of Copenhagen Denmark
Models, Molecular, Molecular Sequence Data, Microfluidic Analytical Techniques, Crystallography, X-Ray, Ligands, Receptors, N-Methyl-D-Aspartate, Communications, High-Throughput Screening Assays, Pyridazines, Death-Associated Protein Kinases, Kinetics, Gene Expression Regulation, Catalytic Domain, Benzamides, Humans, Amino Acid Sequence, Phosphorylation, Protein Kinase Inhibitors, Enzyme Assays, Protein Binding
Models, Molecular, Molecular Sequence Data, Microfluidic Analytical Techniques, Crystallography, X-Ray, Ligands, Receptors, N-Methyl-D-Aspartate, Communications, High-Throughput Screening Assays, Pyridazines, Death-Associated Protein Kinases, Kinetics, Gene Expression Regulation, Catalytic Domain, Benzamides, Humans, Amino Acid Sequence, Phosphorylation, Protein Kinase Inhibitors, Enzyme Assays, Protein Binding
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