Engineering Biofilms for Biocatalysis

descriptionPublicationkeyboard_double_arrow_right Article 23 May 2011 English Publisher:WileyJournal:ChemBioChem, volume 12, pages 1,391-1,395 (issn: 1439-4227, eissn: 1439-7633,

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Authors: Tsoligkas, Andreas N.; Winn, Michael; Bowen, James; Overton, Tim W.; Simmons, Mark J. H.; Goss, Rebecca J. M.;

doi: 10.1002/cbic.201100200

pmid: 21608096

Engineering Biofilms for Biocatalysis

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Abstract

Biofilm, friend not foe: Single species biofilms can be engineered to form robust biocatalysts with greater catalytic activity and significantly improved catalytic longevity than purified and immobilised enzymes. We report the engineering, structural analysis and biocatalytic capability of a biofilm that can mediate the conversion of serine and haloindoles to halotryptophans.

Related Organizations

University of Birmingham
United Kingdom
University of East Anglia
United Kingdom

Keywords

Indoles, Molecular Structure, Surface Properties, Biofilms, Biocatalysis, Serine, Tryptophan, Tryptophan Synthase, Microscopy, Atomic Force, Protein Engineering

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