ABSTRACTCitrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant, antimicrobial, anti‐inflammatory, mitoprotective, and neuroprotective activity. Research on their broad‐scope bioactivity experienced a renaissance in the early 2000s, and further accelerated after COVID‐19, including research on their antimicrobial properties. Summarizing selected research achievements on the antimicrobial activity of the main Citrus flavonoids, this study aims to provide a unified picture on the antimicrobial properties of these valued compounds that will hopefully assist in the development of flavonoid‐based antimicrobials, including antibacterial treatments suitable for clinical use minimizing antimicrobial resistance.