Netamines O–S, Five New Tricyclic Guanidine Alkaloids from the Madagascar Sponge Biemna laboutei, and Their Antimalarial Activities
Copyright policy )Netamines O–S, Five New Tricyclic Guanidine Alkaloids from the Madagascar Sponge Biemna laboutei, and Their Antimalarial Activities
AbstractIn our continuing program to isolate new compounds from the Madagascar sponge Biemna laboutei, five new tricyclic guanidine alkaloids, netamines O – S (1–5, resp.), have been identified together with the known compounds netamine E (6) and mirabilin J (7). The structures of all new netamines were assigned on the basis of spectroscopic analyses. Their relative configurations were established by analysis of ROESY data and comparison with literature data. Netamines O, P, and Q, which were isolated in sufficient quantities, were tested for their cytotoxic activities against KB cells and their activities against the malaria parasite Plasmodium falciparum. Netamines O and Q were found to be moderately cytotoxic. Netamines O, P, and Q exhibited antiplasmodial activities with IC50 values of 16.99±4.12, 32.62±3.44, and 8.37±1.35 μM, respectively.
- Aix-Marseille University France
- French National Centre for Scientific Research France
- Tel Aviv University Israel
- UNIVERSITE D'AIX MARSEILLE France
- Institut de Chimie France
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, Biemna laboutei, Plasmodium falciparum, Molecular Conformation, Sciences de la santé humaine, Guanidines, Antimalarials, Structure-Activity Relationship, Alkaloids, Parasitic Sensitivity Tests, Madagascar, Animals, Human health sciences, Netamines O - S, Pharmacy, pharmacology & toxicology, Cytotoxic activity, Dose-Response Relationship, Drug, Netamines O - S, Pharmacie, pharmacologie & toxicologie, Porifera, [CHIM.OTHE] Chemical Sciences/Other, Antiplasmodial activity, Guanidine alkaloids
[CHIM.ANAL] Chemical Sciences/Analytical chemistry, Biemna laboutei, Plasmodium falciparum, Molecular Conformation, Sciences de la santé humaine, Guanidines, Antimalarials, Structure-Activity Relationship, Alkaloids, Parasitic Sensitivity Tests, Madagascar, Animals, Human health sciences, Netamines O - S, Pharmacy, pharmacology & toxicology, Cytotoxic activity, Dose-Response Relationship, Drug, Netamines O - S, Pharmacie, pharmacologie & toxicologie, Porifera, [CHIM.OTHE] Chemical Sciences/Other, Antiplasmodial activity, Guanidine alkaloids
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