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Dynamic prediction of cumulative incidence functions by direct binomial regression

Authors: Grand, Mia K.; de Witte, T.J.M.; de Witte, T.J.M.; Putter, Hein;

Dynamic prediction of cumulative incidence functions by direct binomial regression

Abstract

AbstractIn recent years there have been a series of advances in the field of dynamic prediction. Among those is the development of methods for dynamic prediction of the cumulative incidence function in a competing risk setting. These models enable the predictions to be updated as time progresses and more information becomes available, for example when a patient comes back for a follow‐up visit after completing a year of treatment, the risk of death, and adverse events may have changed since treatment initiation. One approach to model the cumulative incidence function in competing risks is by direct binomial regression, where right censoring of the event times is handled by inverse probability of censoring weights. We extend the approach by combining it with landmarking to enable dynamic prediction of the cumulative incidence function. The proposed models are very flexible, as they allow the covariates to have complex time‐varying effects, and we illustrate how to investigate possible time‐varying structures using Wald tests. The models are fitted using generalized estimating equations. The method is applied to bone marrow transplant data and the performance is investigated in a simulation study.

Countries
Netherlands, Denmark
Keywords

Biometry, Models, Statistical, dynamic prediction, Radboud University Medical Center, landmarking, Risk Assessment, Statistics, Nonparametric, Applications of statistics to biology and medical sciences; meta analysis, Tumorimmunology - Radboud University Medical Center, Radboudumc 2: Cancer development and immune defence RIMLS: Radboud Institute for Molecular Life Sciences, direct binomial regression, Leukemia, Myeloid, Humans, Regression Analysis, Haematology - Radboud University Medical Center, inverse probability weighting, competing risks, Stem Cell Transplantation

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
8
Top 10%
Average
Top 10%
Related to Research communities
Cancer Research
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