
pmid: 26360927
Analyzing the collected evidence of a systematic review in form of a network meta‐analysis (NMA) enjoys increasing popularity and provides a valuable instrument for decision making. Bayesian inference of NMA models is often propagated, especially if correlated random effects for multiarm trials are included. The standard choice for Bayesian inference is Markov chain Monte Carlo (MCMC) sampling, which is computationally intensive. An alternative to MCMC sampling is the recently suggested approximate Bayesian method of integrated nested Laplace approximations (INLA) that dramatically saves computation time without any substantial loss in accuracy. We show how INLA apply to NMA models for summary level as well as trial‐arm level data. Specifically, we outline the modeling of multiarm trials and inference for functional contrasts with INLA. We demonstrate how INLA facilitate the assessment of network inconsistency with node‐splitting. Three applications illustrate the use of INLA for a NMA.
Statistics and Probability, Biometry, Integrated nested Laplace approximations, Node-splitting, Bayesian inference, Myocardial Infarction, 610 Medicine & health, Applications of statistics to biology and medical sciences; meta analysis, Fibrinolytic Agents, Meta-Analysis as Topic, node-splitting, Humans, 1804 Statistics, Probability and Uncertainty, 2613 Statistics and Probability, Network meta-analysis, network meta-analysis, Clinical Trials as Topic, integrated nested Laplace approximations, Statistics, Bayes Theorem, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), General Medicine, Markov Chains, Acute Disease, Probability and Uncertainty, Smoking Cessation, Monte Carlo Method, Software
Statistics and Probability, Biometry, Integrated nested Laplace approximations, Node-splitting, Bayesian inference, Myocardial Infarction, 610 Medicine & health, Applications of statistics to biology and medical sciences; meta analysis, Fibrinolytic Agents, Meta-Analysis as Topic, node-splitting, Humans, 1804 Statistics, Probability and Uncertainty, 2613 Statistics and Probability, Network meta-analysis, network meta-analysis, Clinical Trials as Topic, integrated nested Laplace approximations, Statistics, Bayes Theorem, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), General Medicine, Markov Chains, Acute Disease, Probability and Uncertainty, Smoking Cessation, Monte Carlo Method, Software
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