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Biometrical Journal
Article . 2015 . Peer-reviewed
License: Wiley Online Library User Agreement
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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Article . 2015
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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Network meta‐analysis with integrated nested Laplace approximations

Network meta-analysis with integrated nested Laplace approximations
Authors: Sauter, Rafael; Held, Leonhard;

Network meta‐analysis with integrated nested Laplace approximations

Abstract

Analyzing the collected evidence of a systematic review in form of a network meta‐analysis (NMA) enjoys increasing popularity and provides a valuable instrument for decision making. Bayesian inference of NMA models is often propagated, especially if correlated random effects for multiarm trials are included. The standard choice for Bayesian inference is Markov chain Monte Carlo (MCMC) sampling, which is computationally intensive. An alternative to MCMC sampling is the recently suggested approximate Bayesian method of integrated nested Laplace approximations (INLA) that dramatically saves computation time without any substantial loss in accuracy. We show how INLA apply to NMA models for summary level as well as trial‐arm level data. Specifically, we outline the modeling of multiarm trials and inference for functional contrasts with INLA. We demonstrate how INLA facilitate the assessment of network inconsistency with node‐splitting. Three applications illustrate the use of INLA for a NMA.

Country
Switzerland
Related Organizations
Keywords

Statistics and Probability, Biometry, Integrated nested Laplace approximations, Node-splitting, Bayesian inference, Myocardial Infarction, 610 Medicine & health, Applications of statistics to biology and medical sciences; meta analysis, Fibrinolytic Agents, Meta-Analysis as Topic, node-splitting, Humans, 1804 Statistics, Probability and Uncertainty, 2613 Statistics and Probability, Network meta-analysis, network meta-analysis, Clinical Trials as Topic, integrated nested Laplace approximations, Statistics, Bayes Theorem, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), General Medicine, Markov Chains, Acute Disease, Probability and Uncertainty, Smoking Cessation, Monte Carlo Method, Software

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Top 10%
Top 10%
Top 10%
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