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Arthritis & Rheumatology
Article . 2025 . Peer-reviewed
License: CC BY NC ND
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PubMed Central
Other literature type . 2025
License: CC BY NC ND
Data sources: PubMed Central
Arthritis & Rheumatology
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Gout and NLRP3 Inflammasome Biology

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 25 Jun 2025 English Publisher:WileyJournal:Arthritis & Rheumatology, volume 77, pages 1,317-1,326 (issn: 2326-5191, eissn: 2326-5205, Copyright policy )
Authors: Raewyn Poulsen; Nicola Dalbeth;

doi: 10.1002/art.43215

pmid: 40322858

Gout and NLRP3 Inflammasome Biology

Abstract

This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail. Treatment strategies for gout are outlined in the context of the mechanisms of NLRP3 inflammasome–mediated acute inflammation.image

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Top 10%
Average
Average
Green
hybrid