Methyltransferase‐Directed Derivatization of 5‐Hydroxymethylcytosine in DNA
Copyright policy )Methyltransferase‐Directed Derivatization of 5‐Hydroxymethylcytosine in DNA
Cytosine modification by AdoMet–dependent DNA methyltransferases is part of an epigenetic regulatory network in vertebrates. Here we show that, in the absence of AdoMet, bacterial cytosine-5 methyltransferases can catalyze condensation of aliphatic thiols and selenols to 5-hydroxymethylcytosine in DNA yielding 5-chalcogenomethyl derivatives. These new atypical reactions open new ways for sequence-specific derivatization and analysis of 5-hydroxymethylcytosine, a recently discovered nucleobase in mammalian DNA
- Vilnius University Lithuania
Cytosine, S-Adenosylmethionine, 5-Methylcytosine, DNA, DNA (Cytosine-5-)-Methyltransferases, Sulfhydryl Compounds, DNA Methylation, Selenium Compounds
Cytosine, S-Adenosylmethionine, 5-Methylcytosine, DNA, DNA (Cytosine-5-)-Methyltransferases, Sulfhydryl Compounds, DNA Methylation, Selenium Compounds
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